Table 3.
Effects of subretinal Aβ on global retinal function assessed by scotopic full-field electroretinography. Retinal function was assessed 1 and 2 weeks post-injection with either Aβ1-42 (n = 7) or vehicle (n = 6). Data shown as an average percentage change from baseline +/- the standard error of the mean (SEM) to account for intra-animal variability. Statistical significance was assessed between groups using the Mann–Whitney U test which showed no change in A-wave (p = 0.945, p = 0.988), B-wave (p = 0.534, p = 0.683), T(A) (p = 0.445, p = 0.098) and T(B) (p = 0.731, p = 0.564) recordings after 1 and 2 weeks, respectively. These findings suggest that subretinal Aβ accumulation does not significantly impact retinal function when measured across the whole retina.
| ERG Component | Week 1 | Week 2 | ||
|---|---|---|---|---|
| Vehicle | Aβ | Vehicle | Aβ | |
| A Wave | 39.3 ± 40.2 | 25.7 ± 24.6 | 100.2 ± 71.3 | 98.8 ± 63.1 |
| B Wave | −7.1 ± 19.6 | 4.7 ± 12.0 | 34.8 ± 32.1 | 53.5 ± 30.7 |
| T(A) | −10.1 ± 9.4 | 7.2 ± 12.2 | −17.4 ± 7.0 | −0.8 ± 6.0 |
| T(B) | −41.3 ± 19.3 | −49.3 ± 14.3 | −37.6 ± 19.9 | −52.3 ± 15.2 |