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EP4 agonist-treated mice showed increased proliferation of tubular cells in vivo. Fourteen days after NTS induction, mice treated with vehicle, high-dose EP4 receptor agonist or low-dose EP4 receptor agonist were evaluated for PCNA+ tubular cells per six high power fields (HPF). Means are indicated by horizontal lines. Statistical significances are provided compared to vehicle-treated mice (* p ≤ 0.05).
