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. 2021 Feb 19;10(2):163. doi: 10.3390/biology10020163

Figure 1.

Figure 1

Overview of DNA damage and repair pathways. Classes of endogenous and exogenous DNA damage inducers in neurons and glia cells. Proteins involved in DNA damage response are shown under the heading of the main pathway they act or respond through. For a complete list of mitochondrial and nuclear DNA repair genes, readers are referred to recent comprehensive reviews [21,43]. A selection of proteins known or proposed to contribute to neurodegenerative disease (NDD) pathogenesis is highlighted in red. Selected proteins involved in mitochondrial DNA (mtDNA) damage repair are highlighted in purple. IR: ionizing radiation. Created with BioRender.com.