Table 1.

Different model systems to study NDDs and the involvement of DDR. The table shows various model systems that have been used to study the role of DDR in various NDDs. Xeroderma Pigmentosum, CS: Cockayne Syndrome.

Model	DDR Genes	NDD	References
C. elegans	PARP1	AD	[146]
	TARDBP	ALS	[183]
	PARP1	AT	[140]
	XPA	XP	[184]
	CSB	CS	[184]
	ATM	AT	[184]
D. melanogaster	ATM	AT	[72]
		AD	[120]
		HD	[122]
D. rerio	C9ORF72	ALS	[185]
	ATM	AT	[186]
M. musculus	ATM	HD	[122]
		AD	[72]
	BRCA1	ALS	[129]
		AD	[73]
	POLβ	AD	[80]
	OGG1	PD	[91]
		ALS	[112]
	ERCC1	PD	[87]
	PARP1	AD	[145]
		PD	[147]
		ALS	[150]
R. norvegicus	ATM	PD	[123]
iPSCs	BRCA1	AD	[128]
	NEK1	ALS	[110]