Scheme 6.
Synthesis of new piperazinyl derivatives of acetyl betulinic acid. Reagents and conditions: (i) ClCOCOCl, 0 °C, 3 h; TEA, N-tert-butoxycarbonyl-1,4-bis(3-aminopropyl)piperazine, RT, 24 h; (ii) TFA 10%/CH2Cl2, RT, 6 h.
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