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The enzyme family of NADPH oxidases consists of Nox1, Nox2, Nox3, Nox4, Nox5, and the dual oxidases Duox1 and Duox2. Different stimuli can trigger ROS production by Nox1, 2 and 3, whereas Nox4 is considered to be constitutively active. Nox5, Duox1 and Duox2 are activated by calcium binding through their cytosolic EF-hand calcium binding domains.
