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. 2021 Feb 17;13(2):312. doi: 10.3390/v13020312

Figure 2.

Figure 2

Sequence alignment between the relevant portion (a red square highlights the interacting sequence and one extra residue at the C-terminal portion, either Tyr or Phe) of the C-terminal domain of SARS-CoV-2, MERS-CoV and SARS-CoV N proteins and the N proteins of representative bat coronaviruses. The sequence conservation for the interacting portion with MASP-2 suggests the potential for these bat coronaviruses to induce severe lung injury in humans. Conserved residues are highlighted in light blue, with the only variable position highlighted in lilac. Evidence from SARS-CoV, MERS-CoV and SARS-CoV-2 indicate that variations in this position are tolerated and do not affect its binding to MASP-2. N protein sequences were downloaded from UniProt [10]. Sequence alignments were performed with Clustal Omega [11]. In the sequence alignment, ‘*’ indicates conserved residues, ‘:’ indicates conserved substitutions, while ‘.’ indicates semiconserved substitutions [11].