Molecular surface representation of the MASP-2 active site (PDB ID 1Q3X), with a reference known inhibitor (PDB ID 3TVJ) added to highlight the catalytic pocket. Residues of the catalytic triad (His483, Asp532, Ser633) are labelled. The surface is colour-coded according to lipophilicity (green = lipophilic, pink = hydrophilic, white = neutral). MASP-2 is represented as lilac ribbon, with carbon atoms for the amino acid residues of the active site shown in lilac. The central portion of the reference peptide inhibitor is shown as cyan ribbon, with carbon atoms for the residues shown in cyan.