Figure 10.

Surface representation of MASP-2 C-terminal region in complex with the substrate C4 (PDB code 4FXG). MASP-2 domains are represented as molecular surface: CCP1 in dark blue, CCP2 in light blue and SP in lilac. C4 is represented as green ribbon. The regions excluded from the docking study with SARS-CoV-2 N protein are highlighted as an overlapping yellow surface (MASP-2 contact surface with C4), or as a pink surface (activation peptide and interacting portions between the two forms, zymogen and active enzyme, of MASP-2). Druggable sites located on the MASP-2 C-terminal region available for binding to coronaviral N proteins are shown (PDB code 4FXG), as identified using the Site Finder tool in MOE 2019.10 [15]: white spheres represent zones suitable for hydrophobic interactions while red spheres represent suitable centers for the potential formation of hydrogen bonds or electrostatic interactions.