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Validation methods for targeted protein degradation at different stages of the ubiquitin-proteasome pathway. P97 PDB: 5FTJ; model of CRL4CRBN E3 ligase apo structure and structure with BRD4 created with PDB: 4A0C (chain C and D), PDB: 4A0K (chain C) and 6BOY (chain B and C); Human 26S proteasome PDB: 5GJR;Ubiquitin PDB: 1UBQ;POI BRD4 PDB: 6BOY (chain C). Structure visualizations created with the Illustrate program101.
