Table 4.

Interactions of different drugs with Mpro.

Drug	Interactions
Digoxin	Thr24, Thr25, Thr26, Thr45, Met49, Leu141, Asn142, Gly143, Cys145, His164, Met165, Glu166, Pro168, Gln189, Thr190
Hexachlorophene	Met49, Cys145, His164, Met165, Glu166
Bazedoxifene	Thr25, Thr26, Leu27, His41, Met49, Tyr54, Asn142, Gly143, Cys145, His164, Met165, Gln166, Asp187, Arg188, Gln189,
Dronedarone	Thr25, Thr26, Met49, Phe140, Leu141, Asn142, Gly143, Cys145, His163, Met165, Glu166, Pro168, Gln189, Thr190, Ala191
Thioridazine	His41, Asn142, Met49, Tyr54, Leu141, His164, Met165, Glu166, Asp187, Arg188, Gln189, Thr190
Chloroquine	His41, Met49, Tyr54, Cys145, His164, Met165, Glu166, Asp187, Arg188, Gln189, Thr190, Gln192
Remdesivir	His41, Thr25, Thr26, Leu27, Met49, Phe140, Leu141, Asn142, Gly143, Ser144, Cys145, His163, His164, Met165, Glu166, Asp187, Arg188, Gln189
DB03259	His41, Asn142, Gly143, Ser144, His163, Cys145, His164, Met165, Gln189
DB01980	His41, Asn142, Cys145, His164, Met165, Glu166, Arg188, Gln189
DB02438	Phe140, Leu141, Asn142, Gly143, Ser144, Cys145, His163, His164, Met165, Glu166
DB02213	His41, Leu141, Asn142, Gly143, Cys145, His164, Met165, Glu166, Asp187, Arg188, Gln189
DB08476	His41, Cys145, His164, Met165, Glu166, Asp187, Arg188, Gln189
DB07287	His41, Met49, Tyr54, His164, Met165, Glu166, Pro168, Asp187, Gln189, Thr190, Ala191

Hydrogen bonds in bold.