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. 2021 Feb 19;22(4):2081. doi: 10.3390/ijms22042081

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The migration of primary microglial cells through inserts with 8 µm pores. (A) The migration rate of primary microglial cells after the spared nerve injury (SNI) surgery is reduced compared with sham conditions. Histograms showing the contribution of each potassium channel, Kv1.3, Kv1.5 and Kir2.1, to microglial migration, in both sham (B–D) and SNI conditions (E–G). All the statistical analysis is represented as Mean ± SD, *: p < 0.05, ***: p < 0.001, using the nonparametric Mann–Whitney test (n = 3 independent experiments).