Table 2.
Characteristics | Normoweight | Overweight | Obese | p-Value between Weight Status Tiers | ||||||
---|---|---|---|---|---|---|---|---|---|---|
Boys (n = 9) |
Girls (n = 12) |
Total (n = 21) |
Boys (n = 9) |
Girls (n = 13) |
Total (n = 22) |
Boys (n = 24) |
Girls (n = 17) |
Total (n = 41) |
||
Age (years) | 12.3 ± 2.2 | 11.9 ± 1.7 | 12.0 ± 1.9 | 12.0 ± 1.8 | 10.9 ± 2.1 | 11.4 ± 2.0 | 11.3 ± 2.3 | 11.1 ± 1.9 | 11.2 ± 2.1 | NS |
Prepubertal/pubertal (n) | 4/5 | 1/11 | 5/16 | 2/7 | 3/10 | 5/17 | 13/11 | 3/14 | 16/25 | NS |
Body weight (kg) | 45.2 ± 13.9 | 41.2 ± 11.6 ‡ | 42.8 ± 12.3 ‡‡‡ | 57.7 ± 13.3 | 55.9 ± 9.9 * | 56.6 ± 11.2 ‡‡* | 71.2 ± 24.3 * | 69.9 ± 14.0 *** | 70.6 ± 20.5 | <0.001 |
Height (m) | 1.53 ± 0.16 | 1.48 ± 0.13 | 1.50 ± 0.14 | 1.55 ± 0.17 | 1.49 ± 0.1 | 1.52 ± 0.13 | 1.5 ± 0.12 | 1.5 ± 0.1 | 1.51 ± 0.11 | ΝS |
BMI (kg/m2) | 18.8 ± 2.4 ‡‡‡ | 18.3 ± 2.6 ‡‡‡ | 18.5 ± 2.5 ‡‡‡ | 23.7 ± 1.0 ** | 24.9 ± 1.7 *** | 24.4 ± 1.6 ‡‡‡*** | 30.0 ± 3.2 *** | 29.6 ± 3.3 *** | 29.8 ± 3.22 | <0.001 |
BMIz | 0.4 ± 0.62 ‡‡‡ | 0.03 ± 1.02 ‡ | 0.18 ± 0.88 ‡‡‡ | 2.03 ± 0.48 *** | 2.24 ± 0.4 *** | 2.15 ± 0.43 ‡‡‡*** | 3.57 ± 0.77 *** | 2.98 ± 0.56 *** | 3.33 ± 0.74 | <0.001 |
Waist circumference (cm) | 64 ± 9.7 ‡ | 64.4 ± 8.1 ‡ | 64.2 ± 8.6 ‡‡‡ | 84.6 ± 4.7 * | 86.6 ± 9.3 *** | 85.8 ± 7.7 ‡‡‡*** | 100.3 ± 17.7 *** | 100.4 ± 12.4 *** | 100.33 ± 15.53 | <0.001 |
Hips circumference (cm) | 78.1 ± 10.3 | 81.0 ± 9.3 ‡ | 79.7 ± 9.6 ‡‡‡ | 91.3 ± 8.5 | 94.3 ± 8.9 ** | 93.1 ± 8.6 ‡‡‡ ** | 101.3 ± 13.9 *** | 103.1 ± 7.8 *** | 102.05 ± 11.67 | <0.001 |
Waist/hips ratio | 0.82 ± 0.02 | 0.8 ± 0.05 | 0.81 ± 0.04 ‡‡‡ | 0.93 ± 0.06 ** | 0.92 ± 0.04 *** | 0.92 ± 0.05 ‡‡‡** | 0.99 ± 0.08 *** | 0.97 ± 0.08 *** | 0.98 ± 0.08 | <0.001 |
hs-CRP (mg/dL) | 0.13 ± 0.09 | 0.14 ± 0.09 | 0.13 ± 0.09 | 0.23 ± 0.16 | 0.28 ± 0.27 | 0.26 ± 0.23 | 0.78 ± 1.32 | 0.39 ± 0.33 | 0.62 ± 1.04 | 0.040 |
Glucose (mg/dL) | 75.7 ± 7.0 | 82.4 ± 6.4 | 79.5 ± 7.3 ‡‡‡ | 84.2 ± 7.5 | 84.3 ± 8.1 | 84.3 ± 7.6 | 88.5 ± 7.8 *** | 87.5 ± 6.0 | 88.1 ± 7.03 | <0.001 |
Insulin (μUI/mL) | 2.6 ± 1.5 | 3.1 ± 2.4 | 2.9 ± 2.1 ‡‡‡ | 5.6 ± 4.8 | 7.4 ± 5.1 | 6.6 ± 4.9 | 13.5 ± 17.1 | 12.4 ± 8.0 *** | 13.07 ± 13.93 | 0.001 |
TG/HDL | 0.9 ± 0.5 | 1.3 ± 0.5 | 1.1 ± 0.5 ‡‡ | 1.8 ± 1.1 | 2.1 ± 1.3 | 1.9 ± 1.2 | 2.0 ± 1.3 * | 2.3 ± 1.4 | 2.13 ± 1.31 | 0.006 |
HOMA-IR | 0.5 ± 0.3 | 0.6 ± 0.5 | 0.6 ± 0.4 ‡‡ | 1.2 ± 1.2 | 1.6 ± 1.2 | 1.4 ± 1.2 | 3.1 ± 4.2 | 2.7 ± 1.7 *** | 2.92 ± 3.34 | 0.001 |
VO2max (mL/kg/min) | 48.3 ± 6.9 ‡ | 46.4 ± 7.6 | 48.7 ± 6.2 ‡‡‡ | 38.1 ± 6.7 ** | 33.6 ± 5.0 *** | 35.7 ± 6.0 ***‡‡‡ | 31.5 ± 5.9 *** | 28.4 ± 5.3 *** | 30.38 ± 5.95 | <0.001 |
VO2max (%) | 95.7 ± 8.2 ‡ | 107.5 ± 15.4 | 102.9 ± 14.1 ‡‡‡ | 74.1 ± 14.0 ** | 74.9 ± 11.1 *** | 75.1 ± 12.1 ***‡‡‡ | 58.5 ± 11.1 *** | 65 ± 11.8 *** | 61.32 ± 11.74 | <0.001 |
Leptin (ng/mL) | 4.0 ± 3.2 ‡ | 6.5 ± 3.5 | 5.5 ± 3.5 ‡‡‡ | 21.9 ± 12.7 * | 30 ± 9.3 *** | 25.5 ± 11.8 ***‡‡‡ | 37.1 ± 16.0 *** | 42.5 ± 20.7 *** | 39.65 ± 18.98 | <0.001 |
Adiponectin (μg/mL) | 15.8 ± 6.5 | 14.9 ± 6.8 | 15.3 ± 6.5 | 14.5 ± 5.2 | 14.9 ± 9.2 | 14.7 ± 7.5 | 13.1 ± 5.7 | 10.5 ± 3.9 | 12.06 ± 5.15 | NS |
Fibrinogen (mg/dL) | 235.6 ± 68.8 | 253.5 ± 69.3 | 245.0 ± 67.8 ‡‡‡ | 324.2 ± 61.7 * | 302.4 ± 87.9 | 311.0 ± 77.4 *‡‡ | 373.4 ± 61.2 *** | 384.4 ± 99.5 *** | 378.0 ± 78.4 | 0.001 |
BMI: body mass index; BMIz: BMI z-score [30,31]; HDL: high-density lipoprotein; HOMA-IR: homeostatic model assessment for insulin resistance; hs-CRP: high-sensitivity C-reactive protein; NS: not significant; SD: standard deviation; TG: triglycerides; VO2max: maximal aerobic capacity; ‡ Statistically different compared to the children of the same sex, with obesity, based on the post-hoc analyses (‡‡‡ p ≤ 0.001, ‡‡ p ≤ 0.01, ‡ p < 0.05); * statistically different compared to the normoweight children of the same sex, based on post-hoc analyses (*** p ≤ 0.001, ** p ≤ 0.01, * p < 0.05).