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LBN reduces self-administration of a low dose of morphine in male rats. LBN exposure reduced self-administration on FR1 (A) and PR (B) of a low dose of morphine (0.25 mg/kg/infusion) in male rats. *P < 0.05. LBN did not significantly alter FR1 (C) or PR (D) for this low dose in females. FR1 and PR for the high dose of morphine (0.75 mg/kg/infusion) was not affected by LBN in male rats (E and F) or female rats (G and H).
