. Author manuscript; available in PMC: 2021 Mar 2.

Published in final edited form as: Neurotoxicol Teratol. 2020 May 5;80:106888. doi: 10.1016/j.ntt.2020.106888

Appendix B.

Inclusion and exclusion criteria

	Inclusion	Exclusion
Population	Infants-Adolescents ages 0–20 years old. No geographic restrictions.	Participants older than 20 years old.
Exposure: blood lead levels	Sample mean blood lead levels ≤10 micrograms/dl Cord blood or postnatal lead levels.	Sample mean blood lead levels >10 micrograms/dl Dentin or bone lead levels. Maternal blood lead levels only.
Outcome: executive function	Assessments of the domains either 1. Cognitive flexibility (shifting) 2. Working memory (updating) 3. Inhibition control (inhibition) 4. Attention 5. Unitary executive functioning. Direct child studies or teacher/parent reports. Individual subtests of general cognition tools.	Assessments of ‘general’ cognition or IQ. Disorder diagnosis (i.e. ADHD, autism, etc.) Assessments of motor, sensory, or auditory abilities.
Study design	Longitudinal/long-term/Cross-sectional design. Studies assessing the association between lead exposure and executive functioning. No intervention. Correlational/observational design.	Studies assessing the combined impact of lead exposure and another predictor (ex. mercury) on executive functioning. Studies including an intervention. Animal studies.
Language	Studies written in English.	Any other language.
Publication	Published paper, dissertations/thesis to reduce publication	Editorials, poster presentations, opinion pieces.