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. Author manuscript; available in PMC: 2021 Mar 2.
Published in final edited form as: Nat Chem Biol. 2020 Jan 13;16(3):351–360. doi: 10.1038/s41589-019-0444-x

Fig. 6 |. Mapping HsGalNAc-T3 FTC mutations to the structure of TgGalNAc-T3.

Fig. 6 |

a, Structure of TgGalNAc-T3 where human FTC missense mutations are mapped as blue spheres (human residue numbers in parentheses). b, TgGalNAc-T3 structure showing the FTC frameshift and point-nonsense mutations mapped as red spheres (human residue numbers in parentheses). Note the R14Sfs*8 and the R87Tfg*19 mutants in the inset are located in the GalNAc-T3 stem. See Supplementary Figs. 5 and 17 for more information on the structural consequences of these mutations.