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. Author manuscript; available in PMC: 2022 Jan 1.
Published in final edited form as: Alzheimers Dement. 2020 Sep 13;17(1):89–102. doi: 10.1002/alz.12178

Figure 3.

Figure 3

A) Brain charts show associations between chronological age, SPARE-BA, and executive function. The relative diagonal isocontours indicate a similar contribution of age and SPARE-BA to the executive function (FDR corrected P-Value <0.05). Put differently, executive function at a given age cannot be estimated without SPARE-BA, and vice-versa. B-C) Brain charts that show associations between chronological age, SPARE-AD, and cognitive testing. The isocontours of the executive function indicate a stronger association with age compared to SPARE-AD, but the effect of SPARE-AD was significant (FDR corrected P-Value <0.05) and increasing after the age of 65 years old. The isocontours of the memory function showed a stronger association with SPARE-AD compared with age after the age of 70 years old, further underlying the role of AD-like atrophy on memory.