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. Author manuscript; available in PMC: 2021 Mar 2.
Published in final edited form as: Autism Res. 2017 Mar 16;10(7):1221–1238. doi: 10.1002/aur.1765

Table 3.

Comorbidities Associated with Sleep Duration. (A) Reports in the Medical History of Attention Deficit Disorder, Depressive Disorder, and Obsessive Compulsive Disorder were All Independently Associated with Shorter Current Sleep Duration. The Threshold for Significance was Set at a Bonferroni-Corrected P-Value < 6.0 × 10−3. (B) for Associated Comorbidities, Mean Sleep Duration was Compared between Children with the Reported Comorbidity to Those without

Comorbidity βa (95% CI) P-value R2
A
Anxiety Disorder (n = 96/2,540) −10.15 (−25.72, 5.42) 2.0 × 10−1 0.0006
Attention Deficit Disorder (n = 361/2,556) −18.43 (−26.94, −9.92) <1.0 × 10−4 0.0070
Bipolar Disorder (n = 13/2,549) −30.22 (−73.50, 13.05) 1.7 × 10−1 0.0007
Constipation (n = 727/2,702) −3.57 (−10.06, 2.93) 2.8 × 10−1 0.0004
Depressive Disorder (n = 21/2,522) −65.68 (−98.41, −32.94) <1.0 × 10−4 0.0061
Irritable Bowel Disorder (n = 20/2,709) −5.62 (−39.23, 27.99) 7.3 × 10−1 0.0000
Migraines (n = 37/2,524) −25.91 (−50.73, −1.08) 4.1 × 10−2 0.0017
Obsessive Compulsive Disorder (n = 85/2,552) −25.76 (−42.27, −9.22) 2.0 × 10−3 0.0036
Seizures (n = 133/2,556) −4.65 (−17.93, 8.64) 4.9 × 10−1 0.0002
Comorbidity Mean SD
w/Comorbidity
Mean SD
w/o Comorbidity
t (df) d (95% CI) P-value

B
Attention Deficit Disorder 538.84+/−76.87 557.27+/−76.35 4.23 (2554) 0.86 (0.43, 1.29) <1.0 × 10−5
Depressive Disorder 490.00+/−97.37 555.68+/−75.99 3.08 (20.23W) 0.24 (0.13, 0.35) 2.9 × 10−3
Obsessive Compulsive Disorder 529.83+/−86.15 555.69+/−76.05 2.72 (88.68W) 0.34 (0.12, 0.55) 3.9 × 10−2

n = the number of children reported to have the comorbidity/the total number of children with these data available.

a

β-coefficients represent the number of minutes sleep duration decreases given that the parent reported presence of the comorbidity in the proband; WIndicates the use of Welch’s approximation as the variance of sleep duration was unequal between the comparison groups.

SD, sleep duration; df, degrees of freedom.