Table 3.

Prediction of eosinophilic exacerbation by eosinophil levels stratified in stable COPD

Cut off	AUC	P value	Sensitivity	Specificity	PPV	NPV
Eosinophilic exacerbation (cut off eosinophil 2%)
100	0.579	0.021	81	34.8	33.5	81.9
150	0.585	0.013	68	49.0	35.1	79.1
300	0.614	0.001	39	83.8	49.4	77.2
400	0.576	0.027	22	93.1	56.4	74.7
2%	0.587	0.011	72	45.3	34.8	80
3%	0.600	0.004	56	64	38.6	78.2
4%	0.599	0.004	42	77.7	43.3	76.8
Eosinophilic exacerbation (cut off eosinophil 300 cells/uL)
100	0.567	0.042	81.3	32.1	16.1	91.4
150	0.562	0.044	66.7	45.8	16.5	89.5
300	0.634	0.046	45.8	80.9	27.8	90.3
400	0.616	0.048	31.3	92.0	38.5	89.3
2%	0.577	0.043	72.9	42.5	16.9	90.7
3%	0.608	0.044	60.4	61.2	20.0	90.6
4%	0.616	0.046	47.9	75.3	23.7	90

COPD, chronic obstructive pulmonary disease, AUC, area under the ROC curve, PPV, positive predictive value, NPV, negative predictive value