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. 2021 Mar 2;13:54. doi: 10.1186/s13195-021-00789-5

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Associations with CSF markers for individuals divided by CSF Aβ42/Aβ40 ratio. a Heatmap of all significant correlation coefficients for individuals defined as A+ and A−. Spearman rho values are indicated by the colour key and grey colour represents non-significant correlations. Significant differences in slopes for association to t-tau and p-tau are indicated in pink. b Scatterplot of CHL1 levels and t-tau concentration. Both A+ and A− individuals display significant associations between CHL1 levels and t-tau concentration (A+: Spearman rho = 0.69; p = 5E−07, A−: Spearman rho = 0.80; p = 5E−56). c Linear regression revealed a significant difference between the slopes of CSF A+ and CSF A− individuals for the association between CHL1 and t-tau concentration (t = 7.13; p = 1E−09). d Scatterplot of NRCAM levels and Aβ42 concentration. A− individuals displayed a significant correlation between NRCAM levels and Aβ42 concentration (Spearman rho = 0.56, p = 4E−20) but not A+ individuals (Spearman rho = 0.36, p = 0.8). e Linear regression showed no significant difference between slopes of A+ and A− individuals for the association between NRCAM and Aβ42 concentration