Fig. 1.

Blinatumomab induced B-ALL cytotoxicity model for single cell profiling. a Schematic of study of blinatumomab-mediated cytotoxicity in a cell line model. b Specific lysis of target cells after treatment with 0.1 ng/mL blinatumomab for 16 and 48 h. The experiment was conducted in three independent replicates. *P < 0.05; **P < 0.01; ***P < 0.001; two-sided paired Student’s t-test. c A T-distributed stochastic neighbor embedding (t-SNE) projection of all single cells from a cell line model with 5 main clusters in different colors. The identity of each cluster was determined based on its signature genes