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. 2021 Mar 1;22:145. doi: 10.1186/s12864-021-07435-2

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Blinatumomab-induced transcriptional changes and pathway analysis in T cell subclusters. a-b Volcano plot showing differentially expressed genes between a clusters TC5-CD4+ Naïve T and TC6-CD4+ Naïve T-STAT1, b clusters TC7-CD4+ TCM and TC8-CD4+ TCM-IFIT3. Genes with a P value < 0.05 and fold change > 2 are highlighted in red. c Venn plot showing the numbers of genes expressed differentially between the blinatumomab-activated and original clusters. Genes encoding cytokines and chemokines are labeled in red. Genes encoding co-signaling receptors are labeled in blue. TC3 represents the comparison between TC3-CD8+ Activated T and TC2-CD8+ TEM. TC13 represents the comparison between TC13-Activated T, TC0-CD4+ Naïve T, and TC5-CD4+ Naïve T. Activated-Tregs represents the comparison between Activated-Tregs and Resting-Tregs. TC10 represents the comparison between TC10-CD4+ Activated T and TC7-CD4+ TCM. d Pathway enrichment analysis revealed 36 differentially expressed genes listed in the reactome database (https://reactome.org/). The size of the circles is proportional to the Gene Count in the corresponding category. The color of each circle corresponds to the P value. Pathways are ranked according to their P value