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. 2021 Mar 1;22:145. doi: 10.1186/s12864-021-07435-2

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Characterization of T cell subtypes in patient derived B-ALL cytotoxicity model. a A t-SNE projection of all T cells in the patient derived model with 9 subclusters. The identity of each cluster was determined based on its signature genes. b Z-score normalized mean expression of signature genes in each cluster. c The proportion of each cluster in untreated (205BM-B0, 207BM-B0, and 207 L-B0) vs blinatumomab-treated (205BM-B50, 207BM-B50, and 207 L-B50) samples. d Heatmap of the 36 common genes identified in cell line models, differentially expressed between PTC2-CD8+ Activated and PTC0-CD8+ TEM, PTC6-Activated T and PTC3-Naïve T single cells. e Bar plot of the expression of TNFRSF4, TNFRSF18 and LAG3 in clusters PTC3-Naïve T and PTC6-Activated T. The y-axis shows the log2 value of the expression value. Δ represents the log2 value of the fold change