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. 2021 Feb 17;118(8):e2024512118. doi: 10.1073/pnas.2024512118

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Copyright © 2021 the Author(s). Published by PNAS.

This open access article is distributed under Creative Commons Attribution License 4.0 (CC BY).

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Fig. 7. — Comparison of structures of SHLD2.3–REV7₄–TRIP13 and MAD2–p31^comet–CDC20–TRIP13 complexes. (A) Positioning of SHLD2.3-mediated O-REV7–C-REV7 dimer on the surface of TRIP13 following insertion of REV7^NT into the central pore of TRIP13 in the SHLD2.3–REV7₄–TRIP13 structure. (B) Positioning of MAD2–p31comet–CDC20 on the surface of TRIP13 following insertion of MAD2^NT into the central pore of TRIP13. (C) Electrostatic surface representation of the TRIP13 (surface potential at ±5 kT e⁻¹). Intermolecular contact patch between REV7 dimer and TRIP13 are highlighted by labeled yellow circles while the intermolecular contact patch between p31comet and TRIP13 is highlighted by a white circle. Monomers D and E use the consistent acidic surface for p31comet and O-REV7 binding, respectively. The TRIP13 pore is also indicated. The (D) REV7^NT and (E) MAD2^NT residues inserted into the TRIP13 pore.