Table 10.

Correlations between p-tau Thr181 and total tau levels with freezing in the cued phase of a fear-conditioning paradigm

Cued Fear (freezing)
	Pearson		Kendall's tau-b		Spearman's rho
p-tau (Thr181) vs. freezing	Correlation coefficient	p value	Correlation coefficient	p value	Correlation coefficient	p value
Left anterior cortex	.789	.007	.809	.001	.924	< 0.001
Right anterior cortex	.692	.031	.539	.031	.736	.015
Left Hippocampus	.296	.406	.270	.281	.304	.393
Right Hippocampus	.593	.071	.405	.106	.565	.089
Left Amygdala	− .052	.887	.090	.719	.116	.751
Right Amygdala	.323	.363	.315	.209	.438	.206
Left Posterior Cortex	.095	.795	.000	1.000	− .018	.960
Right Posterior Cortex	− .211	.553	.045	.857	− .030	.934
Total tau vs. freezing
Left anterior cortex	.085	.816	.180	.472	.201	.578
Right anterior cortex	.347	.326	.180	.472	.261	.466
Left Hippocampus	− .376	.284	− .360	.151	− .486	.154
Right Hippocampus	− .484	.157	− .315	.209	− .432	.213
Left Amygdala	− .017	.963	− .135	.590	− .243	.498
Right Amygdala	− .581	.078	− .584	.020	− .711	.021
Left Posterior Cortex	− .243	.500	− .180	.472	− .316	.374
Right Posterior Cortex	.393	.262	.360	.151	.523	.121

P-tau Thr181 and total tau levels were previously determined by Western blotting with the antibody AT270 at 40 weeks after blast exposure [21]. P-tau levels were correlated with freezing to the second tone in the cued testing phase of a fear learning task previously found to be affected in the same blast-exposed rats at 35 weeks following blast exposure [80]. Five blast and five control animals were analyzed. Correlations with p values less than 0.05 are indicated in bold