Table 11.
Novel object recognition (short-term memory) | ||||||
---|---|---|---|---|---|---|
p-tau (Thr181) vs. discrimination index | Pearson | Kendall's tau-b | Spearman's rho | |||
Correlation coefficient | p value | Correlation coefficient | p value | Correlation coefficient | p value | |
Left anterior cortex | − .132 | .716 | − .156 | .531 | − .176 | .627 |
Right anterior cortex | − .373 | .289 | − .244 | .325 | − .382 | .276 |
Left Hippocampus | .049 | .893 | − .067 | .788 | − .055 | .881 |
Right Hippocampus | − .026 | .943 | .067 | .788 | − .006 | .987 |
Left Amygdala | − .015 | .967 | − .022 | .929 | − .224 | .533 |
Right Amygdala | − .149 | .680 | − .156 | .531 | − .176 | .627 |
Left Posterior Cortex | .545 | .104 | .511 | .040 | .527 | .117 |
Right Posterior Cortex | .035 | .924 | .200 | .421 | .297 | .405 |
Total tau vs. discrimination index | ||||||
Left anterior cortex | − .330 | .352 | − .333 | .180 | − .491 | .150 |
Right anterior cortex | − .137 | .706 | .022 | .929 | .103 | .777 |
Left Hippocampus | .205 | .570 | .156 | .531 | .200 | .580 |
Right Hippocampus | .052 | .886 | .022 | .929 | .079 | .829 |
Left Amygdala | .337 | .340 | .289 | .245 | .382 | .276 |
Right Amygdala | − .042 | .908 | .156 | .531 | .176 | .627 |
Left Posterior Cortex | .227 | .529 | − .111 | .655 | − .091 | .803 |
Right Posterior Cortex | − .364 | .300 | − .333 | .180 | − .479 | .162 |
P-tau Thr181 levels were previously determined by Western blotting with the antibody AT270 at 40 weeks after blast exposure [21]. P-tau levels were correlated with the discrimination index in a novel object recognition task previously found to be affected in the same blast-exposed rats at 33 weeks following blast exposure [80]. Five blast and five control animals were analyzed. Correlations with p values less than 0.05 are indicated in bold