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. 2021 Mar 2;19:64. doi: 10.1186/s12951-021-00811-w

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — In vivo antitumor efficiency of different treatments: (1) saline (n = 5), (2) Dox@IR825@Gd@CDs (n = 5), (3) IR825@Gd@CDs + 808 nm irradiation (1.5 W, n = 5), (4) Dox@IR825@Gd@CDs + 808 nm irradiation (1.5 W, n = 5): a Temperature curves of 4T1 tumor-bearing mice after treatment. b Thermographic images of 4T1 tumor-bearing mice after treatment. c Tumor volume change curves. d Photographs of 4T1 tumor-bearing mice during different treatments. e Tumor weight collected from mice after 14 days treatments. f Photographs of tumor tissues collected from mice after 14 days treatments. g H&E-stained images of tumor slices. h Body weight changes. i Comparison of mice rotarod test performance between various treatments. j Drug biodistribution of 4T1 tumor-bearing mice following injection of Dox@IR825@Gd@CDs. *P < 0.05; **P < 0.01;***P < 0.005. P values represent the outcome of Multiple Comparisons in Analysis of Variance (ANOVA)