Table 3.
Meta-regression analysis result of outcomes among baseline factors, and patients and treatment characteristics
| Covariate | Coefficient (β) | 95% CI | P-value | |
|---|---|---|---|---|
| TC | Age | 2.63 | 0.22, 5.04 | 0.036 |
| Dose | 0.01 | − 0.01, 0.04 | 0.223 | |
| Duration | − 1.42 | − 2.48, − 0.36 | 0.014 | |
| FBS | 0.80 | − 0.77, 2.39 | 0.268 | |
| TC | − 0.42 | − 0.98, 0.14 | 0.126 | |
| TG | − 0.11 | − 0.73, 0.50 | 0.675 | |
| LDL | − 0.15 | − 0.85, 0.54 | 0.629 | |
| HDL | 0.05 | − 1.55, 1.67 | 0.938 | |
| HgA1C | − 14.96 | − 38.56, 8.63 | 0.177 | |
| BMI | 6.92 | 1.02, 12.82 | 0.028 | |
| TG | Age | 4.22 | − 3.17, 11.62 | 0.224 |
| Dose | − 0.01 | − 0.11, 0.08 | 0.772 | |
| Duration | − 2.10 | − 5.20, 1.00 | 0.158 | |
| FBS | − 1.00 | − 12.72, 10.72 | 0.841 | |
| TC | 0.14 | − 1.77, 2.06 | 0.871 | |
| TG | 0.05 | − 1.67, 1.78 | 0.946 | |
| LDL | 0.48 | − 1.84, 2.80 | 0.647 | |
| HDL | 3.36 | 0.09, 6.63 | 0.045 | |
| HgA1C | 3.72 | − 73.66, 81.12 | 0.912 | |
| BMI | 18.35 | 6.82, 29.88 | 0.007 | |
| LDL | Age | 2.85 | 0.29, 4.82 | 0.031 |
| Dose | 0.02 | 0.00, 0.05 | 0.039 | |
| Duration | − 1.16 | − 2.17, − 0.16 | 0.027 | |
| FBS | 1.12 | − 0.38, 2.64 | 0.122 | |
| TC | − 0.53 | − 1.13, 0.05 | 0.071 | |
| TG | − 0.17 | − 0.84, 0.49 | 0.570 | |
| LDL | − 0.31 | − 1.06, 0.43 | 0.366 | |
| HDL | − 0.10 | − 1.84, 1.63 | 0.893 | |
| HgA1C | − 20.77 | − 41.32, − 0.22 | 0.048 | |
| BMI | 4.88 | − 2.45, 12.21 | 0.159 | |
| HDL | Age | − 1.03 | − 1.63, − 0.42 | 0.004 |
| Dose | − 0.004 | − 0.01, 0.004 | 0.257 | |
| Duration | 0.59 | 0.29, 0.89 | 0.001 | |
| FBS | − 0.25 | − 0.78, 0.26 | 0.281 | |
| TC | 0.15 | − 0.005, 0.31 | 0.057 | |
| TG | − 0.007 | − 0.22, 0.20 | 0.937 | |
| LDL | 0.05 | − 0.16, 0.27 | 0.566 | |
| HDL | − 0.01 | − 0.56, 0.54 | 0.954 | |
| HgA1C | 5.70 | − 1.77, 13.17 | 0.114 | |
| BMI | − 2.27 | − 4.61, 0.06 | 0.055 | |
| FBS | Age | 2.17 | 0.47, 3.87 | 0.018 |
| Dose | 0.002 | − 0.02, 0.02 | 0.848 | |
| Duration | − 0.97 | − 1.73, − 0.21 | 0.018 | |
| FBS | 0.31 | − 1.77, 2.41 | 0.729 | |
| TC | − 0.20 | − 0.74, 0.33 | 0.416 | |
| TG | 0.10 | − 0.46, 0.67 | 0.686 | |
| LDL | 0.03 | − 0.62, 0.69 | 0.916 | |
| HDL | 0.92 | − 0.48, 2.34 | 0.173 | |
| HgA1C | − 9.04 | − 30.38, 12.29 | 0.349 | |
| BMI | 6.29 | 1.23, 12.61 | 0.024 | |
| HgA1C | Age | 0.10 | 0.01, 0.19 | 0.032 |
| Dose | − 0.0001 | − 0.001, 0.001 | 0.964 | |
| Duration | − 0.05 | − 0.08, − 0.02 | 0.003 | |
| FBS | 0.13 | 0.005, 0.262 | 0.044 | |
| TC | − 0.01 | − 0.04, 0.01 | 0.328 | |
| LDL | − 0.002 | − 0.04, 0.04 | 0.879 | |
| HDL | 0.017 | − 0.05, 0.09 | 0.617 | |
| HgA1C | − 0.38 | − 1.48, 0.71 | 0.438 | |
| BMI | 0.27 | 0.00, 0.54 | 0.049 |
BMI body mass index, CI confidence interval, FBS fasting blood sugar, HDL high density lipoprotein, HgA1C hemoglobin A1C, LDL low density lipoprotein, TC total cholesterol, TG total triglycerides. The covariates are baseline factors