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. 2021 Mar 1;18:63. doi: 10.1186/s12974-021-02116-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Mephedrone affects tight junction protein expression and localization in hBMVEC. a Representative immunoblots of occludin, claudin-1, and claudin-5 from cytosolic and membrane fractions of endothelial cells treated with 10 μM mephedrone for 24 h. b The plots represent densitometry analysis of the target band intensity normalized to the GAPDH (cytosolic fraction) or NaK-ATPase (membrane fraction) band intensities and relative to the untreated control. The results are shown as the percentage of the mean value ± SEM. Experiments were independently performed three times. Within each individual experimental set, primary cells from four different donors were used (n = 12)