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ROS accumulation in 3D-cultured constructs following cyclic compressive loading and effects of antioxidant. 3D-cultured constructs with or without cyclic loading were fixed. Cells were then stained with mouse-anti-8OHdG antibody and observed under a microscope. Bar, 20 μm. b) PDTC, an antioxidant, markedly prevented both ADAMTS4 and IL-1R mRNA expressions induced by compressive mechanical stress. Values are given as mean ± SD (n = 6 each). *P < 0.05
