Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Feb 15;118(8):e2011491118. doi: 10.1073/pnas.2011491118

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 the Author(s). Published by PNAS.

This open access article is distributed under Creative Commons Attribution License 4.0 (CC BY).

PMC Copyright notice

Fig. 2. — Overexpression of fkh in neurons, but not glia, extends lifespan independent of FOXO. (A) Images from the SCope database (33) show mRNA expression of fkh largely in nSyb-expressing (neuronal) cell populations in the Drosophila brain. (B) Immunofluorescence images from the cell body layer of the central brain show FKH expression in REPO-negative (neuronal) cells in w^Dah flies. (Scale bar, 10 μm.) (C–E) Survival curves show (C) extended lifespan for w^Dah;UAS-fkh/+;elav-GS/+ flies, (D) no change in lifespan for w^Dah;UAS-fkh/+;GSG3285-1/+ flies, and (E) extended lifespan for both w^Dah;UAS-fkh/+;elav-GS/+ and w^Dah;UAS-fkh/+;elav-GS, foxoΔ/foxoΔ flies treated with 200 μM RU-486 from 2 d of age, with no significant interaction between fkh overexpression and foxoΔ genotype. For all survival experiments, n > 85 deaths were counted per condition; P values are from either log-rank tests between groups (C and D) or Cox proportional hazards testing (E).