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. 2021 Feb 15;118(8):e2011491118. doi: 10.1073/pnas.2011491118

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Copyright © 2021 the Author(s). Published by PNAS.

This open access article is distributed under Creative Commons Attribution License 4.0 (CC BY).

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Fig. 4. — RNA-seq from head mRNA reveals fkh-dependent transcriptional responses to reduced IIS. (A) In head mRNA from flies treated with 200 μM RU-486 or vehicle control from 2 to 5 d of age, the overlap between the transcriptional response from reduced IIS compared with controls (daGS>UAS-InR^DN,UAS-GFP-RNAi induced versus daGS>UAS-InR^DN,UAS-GFP-RNAi uninduced) and compared with flies with reduced IIS and fkh knockdown (daGS>UAS-InR^DN,UAS-GFP-RNAi induced versus daGS>UAS-InR^DN,UAS-fkh-RNAi induced), revealed 99 shared up-regulated and 84 shared down-regulated genes, which represented a significant overlap between comparisons (P = 6.3 × 10⁻⁴⁵ by Fisher’s exact test). (B) Heatmap shows P values for the 20 genes most significantly up-regulated or down-regulated among the shared genes between comparisons.