Table 2.
Absolute (mg) and relative organ weights (mg/g body weight) from female F1 Sprague Dawley rats exposed to deoxynivalenol in utero beginning on gestation day 6 and continuing through lactation1
| Unit | 0 mg/kg/day | 0.03 mg/kg/day | 0.1 mg/kg/day | 0.3 mg/kg/day | 1 mg/kg/day | 3 mg/kg/day | |
|---|---|---|---|---|---|---|---|
| Terminal Body Weight | g | 87.58 ± 3.01 (8) | 85.46 ± 1.55 (5) | 87.96 ± 2.27 (5) | 85.00 ± 1.38 (5) | 92.38 ± 2.25 (5) | 73.36 ± 5.14* (8) |
| Brain | g | 1.63 ± 0.03 (3) | NA | NA | NA | NA | 1.53 ± 0.01* (3) |
| mg/g | 20.27 ± 0.98 (3) | NA | NA | NA | NA | 19.53 ± 0.12 (3) | |
| Thymus | g | 0.42 ± 0.04 (5) | 0.39 ± 0.01 (5) | 0.39 ± 0.02 (5) | 0.42 ± 0.02 (5) | 0.45 ± 0.04 (5) | 0.31 ± 0.05 (5) |
| mg/g | 4.16 ± 0.27 (5) | 4.53 ± 0.09 (5) | 4.47 ± 0.17 (5) | 4.99 ±0.21 (5) | 4.82 ± 0.29 (5) | 4.38 ± 0.52 (5) | |
| Lung | g | 1.14 ± 0.10 (5) | 0.97 ± 0.08 (5) | 1.04 ± 0.08 (5) | 0.93 ± 0.04 (5) | 0.90 ± 0.05 (5)* | 0.65 ± 0.07** (5) |
| mg/g | 12.40 ± 0.91 (5) | 11.26 ± 0.81 (5) | 11.95 ± 1.11 (5) | 10.92 ± 0.52 (5) | 9.70 ± 0.40 (5)* | 9.34 ± 0.32** (5) | |
| Liver | g | 4.44 ± 0.29 (5) | 4.16 ± 0.08 (5) | 4.49 ± 0.18 (5) | 4.22 ± 0.11 (5) | 4.74 ± 0.06 (5) | 3.81 ± 0.48 (5) |
| mg/g | 48.39± 2.22 (5) | 48.71 ± 1.22 (5) | 51.11 ± 1.76 (5) | 49.61 ± 0.68 (5) | 51.41 ± 1.20 (5) | 53.98 ± 1.64 (5) | |
| Spleen | g | 0.31 ± 0.01 (5) | 0.31 ± 0.02 (5) | 0.35 ± 0.01 (5) | 0.31 ± 0.01 (5) | 0.32 ± 0.01 (5) | 0.34 ± 0.03 (5) |
| mg/g | 3.45 ± 0.10 (5) | 3.59 ± 0.23 (5) | 3.98 ± 0.11 (5) | 3.68 ± 0.09 (5) | 3.48 ± 0.13 (5) | 5.10 ± 0.76** (5) | |
| Kidney-left | g | 0.47 ± 0.01 (5) | 0.45 ± 0.01 (5) | 0.47 ± 0.02 (5) | 0.45 ± 0.01 (5) | 0.49 ± 0.01 (5) | 0.39 ± 0.04* (5) |
| mg/g | 5.17 ± 0.13 (5) | 5.25 ± 0.13 (5) | 5.32 ± 0.18 (5) | 5.24 ± 0.07 (5) | 5.28 ± 0.19 (5) | 5.54 ± 0.19 (5) | |
| Kidney-right | g | 0.48 ± 0.01 (5) | 0.45 ± 0.01 (5) | 0.48 ± 0.02 (5) | 0.46 ± 0.01 (5) | 0.49 ± 0.01 (5) | 0.40 ± 0.04* (5) |
| mg/g | 5.21 ± 0.10 (5) | 5.32 ± 0.17 (5) | 5.46 ± 0.18 (5) | 5.37 ± 0.07 (5) | 5.36 ± 0.17 (5) | 5.69 ± 0.20 (5) |
NA- not evaluated
*
Statistically significant at p≤0.05
**
Statistically significant at p≤0.01
N numbers indicated in parentheses
1
Treatments to the dams began on gestation day 6; pups continued to be exposed via direct dosing along with dosing of the dam beginning on PND 12 and continuing until PND 27.