Table 4.

Suggested immunological standard therapies.

Diagnose	Suggested Procedure
APLS Therapy	(1)Thrombotic APLS is recommended to be treated with LDA and heparin in therapeutic dosage during pregnancy (2)In case of refractory OAPLS, increasing heparin to therapeutic dosage or addition of low dose prednisolone or hydroxychloroquine in the first trimester could be considered (3)During pregnancy, treatment with LDA alone or in combination with heparin depending on the individual risk profile is recommended in patients with NC-OAPLS [135] Aspirin until GW 34+0, heparin 6 weeks post-partum (APLS and non-criteria APLS)
Thyroid Antibodies	Thyroid hormone substitution therapy can be administered in woman with RPL and latent hypothyroidism i.e., TPO antibodies
Chronic Endometritis	If detected, a chronic endometritis should be treated First line therapy with doxycycline 200 mg for 14 days. A test of cure should be performed after completion. Second line therapy with metronidazole and ciprofloxacin if test of cure is positive
Other Immunomodulatory Therapies	Glucocorticoids only in clinical studies in women with pre-existing autoimmune disorder therapies with IVIG, alogeneic lymphocyte transfer, lipid infusions or TNF-α-blockers can be considered, however not outside of clinical studies

APLS = antiphospholipid syndrome; IVIG = intravenous immune globulin; TNF-α-blocker = tumor necrosis factor alpha blocker.