Table 1.
Impact of CCR5Δ32 on SARS-CoV-2 infection and the course of the disease.
| CCR5 | SARS-CoV-2 infection |
Evaluable infection* | Symptomatic infection |
Severe RTI |
Respiratory hospitalization |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR | (95%-CI) | p | n | OR | (95%-CI) | p | OR | (95%-CI) | p | OR | (95%-CI) | p | |
| Wild-type homozygous | 1 | 3816 | 1 | 1 | 1 | ||||||||
| CCR5Δ32 homozygous | 1.05 | (0.81–1.36) | 0.70 | 59 | 1.12 | (0.47–2.67) | 0.80 | 0.92 | (0.50–1.70) | 0.80 | 1.21 | (0.29–5.13) | 0.79 |
| CCR5Δ32 + wild-type | 0.95 | (0.88–1.02) | 0.16 | 883 | 1.13 | (0.88–1.46) | 0.34 | 1.04 | (0.88–1.23) | 0.63 | 1.15 | (0.78–1.7) | 0.47 |
| Wild-type homozygous | 1 | 3816 | 1 | 1 | 1 | ||||||||
| CCR5Δ32 present | 0.96 | (0.89–1.03) | 0.21 | 942 | 1.13 | (0.88–1.45) | 0.32 | 1.03 | (0.88–1.22) | 0.68 | 1.16 | (0.79–1.69) | 0.45 |
Legend: CI, confidence interval; n, number of cases; OR, odds ratio; p, p-value; RTI, respiratory tract infection. Odds ratios were calculated in a multivariable logistic regression model containing information on age, sex, BMI, diabetes mellitus, arterial hypertension, smoking status and month of testing.
*
Infections reported for January to July 2020.