Table 1.
Demographic, clinical characteristics and laboratory findings of COVID-19 first and 2nd episodes, from onset of first episode (D1) to last follow-up, Nord Franche-Comte Hospital, France, 2020.
| Patient 1 | Patient 2 | Patient 3 | ||
|---|---|---|---|---|
| Patients characteristics | ||||
| Age, y | 57 | 40 | 32 | |
| Sex | F | F | F | |
| Comorbidities | Asthma (HCW) | None (HCW) | None (HCW) | |
| First episode (onset = D1) | ||||
| Clinical presentation | ILI without fever-AO-DG-cough-sputum production-diarrhea | ILI, chills | ILI | |
| RT-PCRa SARS-CoV-2 | Days from onset | D6 | NA | NA |
| CT if available | POSITIVE (E 27.66 – N NA RdRP 25.62) | |||
| Serology | Days from 1st onset | 59 | 61 | 94 |
| Results | POSITIVE IgG IgM | POSITIVE IgG | POSITIVE IgG (20.2 U/mL) | |
| RT-PCRa SARS-CoV-2 (follow-up) | Days from onset | 236 | 212 | 155 |
| Results | NEGATIVE | NEGATIVE | NEGATIVE | |
| Treatment | None | None | None | |
| Duration of symptoms | 14 | 8 | 7 | |
| Second episode | ||||
| Clinical presentation | Myalgia-fatigue-dyspnea | ILI-chills-headache-tearing-AO-DG-cough-chest pain-dyspnea- | ILI- headache- AO-DG cough-diarrhea | |
| Days from 1st onset (clinical recurrence) | 243 | 219 | 176 | |
| RT-PCR SARS-CoV-2 | Days from 2nd onset | 8 | 7 | 10 |
| CT if available | POSITIVE (E NA – N 40 RdRP NA) | POSITIVE (E 36.93) ORF1 36.4 |
POSITIVE (E 0 – N 38 RdRP 0) | |
| Treatment | None | None | None | |
Abbreviations: AO: anosmia; COVID-19: coronavirus disease 2019; D: day; DG: dysgeusia; ILI: influenza-like illness (fever + myalgia/arthralgia + fatigue + sore throat + nasal congestion); HCW: Health care worker; NA: not available; SARS-CoV-2: severe acute respiratory syndrome coronavirus 2.
a
RT-PCR: real-time reverse transcription Polymerase Chain Reaction: cycle threshold (CT), envelope gene (E), nucleocapsid gene (N), ARN polymerase gene (RdRP), specific Open Reading Frame (ORF)1.