Table 1.
Clinical characteristics of 38 seronegative heath care workers according to incident SARS-CoV-2 infection during the follow up
| Overall N = 38 |
Infected N = 11 |
Not infected N = 27 |
p-value | |
|---|---|---|---|---|
| Age (years) | 38 [22-60] | 41 [25-60] | 36 [22-57] | 0.975 |
| Sex (female) | 21 (55%) | 7 (64%) | 14 (52%) | 0.721 |
| Body Mass Index (Kg/m2) | 23.1 (20.3-25.5) | 23.1 (20-23.6) | 23 (20-26) | 0.612 |
| HCWs1: | 0.582 |
|||
| Physicians | 26 (68%) | 9 (82%) | 17 (63%) | |
| Nurses | 12 (32%) | 2 (18%) | 10 (37%) | |
| Concomitant comorbidities | 0.987 | |||
| Hypertension | 1 (3%) | — | 1 (4%) | |
| Diabetes | 1 (3%) | — | 1 (4%) | |
| Working at COVID-19 ward | 14 (37%) | 4 (36%) | 10 (37%) | 0.287 |
| Exposure to aerosol generating procedures2 | 12 (32%) | 2 (18%) | 10 (37%) | 0.456 |
| Time to evaluation (days)3 | 189 [172-195] | 159 [147-170] | 190 [188-196] | <0.001 |
| Previous T-cell response | ||||
| CD8+ reactive | 20 (53%) | 6 (55%) | 14 (52%) | 0.880 |
| CD4+ reactive | 13 (34%) | 2 (18%) | 11 (41%) | 0.268 |
| SARS-CoV-2 RT-PCR | ||||
| Positive | 9 (24%) | 9 (82%) | — | |
| Negative | 8 (21%) | — | 8 (30%) | |
Data are expressed as median and interquartile range, and percentage. Mann-Whitney U test for statistical differences between variables. HCW, health care workers; RT-PCR, reverse transcriptase- PCR; 1chi-square test; 2aerosol-generating procedures included airway suction, application of a high-flow O2 instrument, bronchoscopy, endotracheal intubation, tracheostomy, nebulizer treatment, sputum induction, positive pressure ventilation, manual ventilation, and cardiopulmonary resuscitation; 3Time from study inclusion to positive RT-PCR testing or final serologic testing, depending of the group.