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. 2021 Feb 4;11:598884. doi: 10.3389/fimmu.2020.598884

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Copyright © 2021 Shao, Meng, Liu, Xu, Wang, Hu, Hou and Ho

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of RIG-I knockout on poly(dA:dT)-mediated inhibtion of HSV-2 gene expression. End1/E6E7 control cells (V2 control) and RIG-I knockout End1/E6E7 cells (RIG-I^−/−) were transfected with or without poly(dA:dT) (0.5μg/ml) for 24h prior to HSV-2 infection (MOI = 0.001). At 24h post HSV-2 infection, cellular RNAs were collected and subjected to the real-time PCR for HSV-2 immediate early genes (A, B), early genes (C, D), and late genes (E, F) expression. The results were measured as HSV-2 gene levels relative (%) to control (without treatment, which is defined as 100%). Data are shown as mean ± SD for three independent experiments. Asterisks indicate that the differences between the indicated groups are statistically significant (*P < 0.05, **P < 0.01).