Table 3.
Association of serum HDL-cholesterol, ApoA1, triglyceride levels with risk of severe SARS-CoV-2 infection
| Trait | Cases versus Unmatched Hospital-Based Controlsa |
Cases versus Matched Hospital-Based Controlsb |
||||||
|---|---|---|---|---|---|---|---|---|
| n | Per 10 mg/dl |
Per IQR |
P | n | Per 10 mg/dl |
Per IQR |
P | |
| OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) | |||||
| HDL-Cholesterol | ||||||||
| Model 1 | 968/3,087 | 0.90 (0.85–0.95) | 0.82 (0.73–0.91) | 4.0 × 10−04 | 620/1,240 | 0.85 (0.78–0.92) | 0.74 (0.63–0.86) | 1.1 × 10−04 |
| Model 2 | 968/3,087 | 0.92 (0.86–0.97) | 0.85 (0.76–0.95) | 5.1 × 10−03 | 620/1,240 | 0.87 (0.79–0.94) | 0.77 (0.65–0.90) | 1.2 × 10−03 |
| ApoA1 | ||||||||
| Model 1 | 966/3,069 | 0.94 (0.92–0.97) | 0.82 (0.73–0.91) | 3.0 × 10−04 | 620/1,240 | 0.93 (0.89–0.96) | 0.76 (0.66–0.88) | 2.2 × 10−04 |
| Model 2 | 966/3,069 | 0.95 (0.92–0.98) | 0.84 (0.75–0.94) | 9.0 × 10−03 | 620/1,240 | 0.93 (0.89–0.97) | 0.78 (0.67–0.91) | 1.2 × 10−03 |
| Triglycerides | ||||||||
| Model 1 | 1,050/3,365 | 1.01 (1.00–1.02) | 1.09 (1.01–1.19) | 0.03 | 670/1,339 | 1.02 (1.00–1.03) | 1.15 (1.04–1.28) | 7.5 × 10−03 |
| Model 2 | 1,050/3,365 | 1.01 (1.00–1.01) | 1.07 (0.99–1.16) | 0.10 | 670/1,339 | 1.01 (1.00–1.03) | 1.14 (1.02–1.26) | 0.02 |
IQR, interquartile range.
Sample sizes (n) indicate number of cases/controls. Data are shown as ORs and 95% CIs.
a
Logistic regression analysis: model 1 was adjusted for age, sex, PC1–10, obesity, hypertension, type 2 diabetes, and CAD. Model 2 included the same covariates as model 1 with additional adjustment for BMI, education, and smoking.
b
Conditional logistic regression analysis: model 1 was only adjusted for PC1–10 and did not include any of the matching variables (age, sex, obesity, hypertension, type 2 diabetes, and CAD). Model 2 was adjusted for PC1–10, BMI, education, and smoking.