Table 4.
Association of ApoE4 alleles with severe SARS-CoV-2 infection and mortality from COVID-19 is independent of serum HDL-cholesterol levels
| Comparison Groups | ApoE Genotypes |
Pa | ||
|---|---|---|---|---|
| E3/E3 | E3/E4 | E4/E4 | ||
| Cases versus unmatched hospital-based controls (n)b | 531/1,763 | 249/770 | 51/79 | |
| Model 1 | 1 | 1.12 (0.94–1.34) | 2.23 (1.58–3.32) | 1.3 × 10−5 |
| Model 2 | 1 | 1.11 (0.93–1.33) | 2.27 (1.56–3.30) | 1.6 × 10−5 |
| Cases versus matched hospital-based controls (n)c | 342/636 | 144/242 | 32/23 | |
| Model 1 | 1 | 1.22 (0.94–1.57) | 3.15 (1.75–5.68) | 1.4 × 10−4 |
| Model 2 | 1 | 1.23 (0.95–1.60) | 3.15 (1.75–5.68) | 1.4 × 10−4 |
| Mortality among cases (yes/no)b | 236/295 | 124/125 | 32/19 | |
| Model 1 | 1 | 1.22 (0.85–1.73) | 2.55 (1.30–5.00) | 6.6 × 10−3 |
| Model 2 | 1 | 1.21 (0.85–1.72) | 2.57 (1.31–5.05) | 6.0 × 10−3 |
Data are shown as ORs and 95% CI.
a
P values are for comparisons between E4/E4 versus E3/E3 groups.
b
Logistic regression analysis: model 1 was adjusted for age, sex, PC1–10, obesity, hypertension, type 2 diabetes, CAD, BMI, education, smoking, and genotyping array. Model 2 was adjusted for the same variables as model 1 with additional adjustment for serum HDL-cholesterol levels.
c
Conditional logistic regression analysis: model 1 was adjusted for PC1–10, BMI, education, smoking, and genotyping array. Model 2 was adjusted for the same variables as model 1 with additional adjustment for serum HDL-cholesterol levels.