Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Feb 25;13:1967–1979. doi: 10.2147/CMAR.S287386

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 Li et al.

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).

PMC Copyright notice

CAR10 is upregulated and associated with a poor prognosis in patients with NSCLC. (A and B) Expression of CAR10 in 50 NSCLC and paired ANT samples was measured using RT-qPCR. ****P<0.0001. CAR10 expression in NSCLC and normal lung tissues or ANTs was analyzed in the (C) GSE19188, (D) GSE30219 and (E) GSE118370 datasets. (F) CAR10 was highly expressed in patients with lymph node metastasis (N1 and N2) compared with those without (N0). **P<0.01 and ^##P<0.01 vs the N0 and N1 groups, respectively. (G) Kaplan-Meier analysis was conducted to determine OS time in the patients with NSCLC and high or low CAR10 expression levels; P=0.0006. (H) The CAR10 expression in a normal human bronchial epithelial cell line (16HBE) and in the A549, H1975, SPCA1 and H1299 NSCLC cell lines was determined using RT-qPCR. ***P<0.001. The data are presented as the mean ± SD from three independent experiments.

Abbreviations: CAR10, chromatin-associated RNA Intergenic 10; NSCLC, non-small cell lung cancer; RT-qPCR, reverse transcription-quantitative PCR; ANT, adjacent normal tissue; OS, overall survival.