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. 2021 Feb 25;13:1967–1979. doi: 10.2147/CMAR.S287386

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© 2021 Li et al.

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CAR10 promotes migration and invasion by upregulating GJB2 in the A549 and H1299 cell lines. GJB2 protein expression level was determined in the (A) A549 and (B) H1299 cells using Western blot analysis, after up- and downregulation of CAR10. **P<0.01. Changes in the metastatic ability of (C) A549 and (D) H1299 cells after different CAR10 and GJB2 interventions were determined using Transwell and Matrigel assays. Not significant, P>0.05 and ***P<0.001. Scale bar, 100 μm. The data are presented as the mean ± SD from three independent experiments.

Abbreviations: CAR10, chromatin-associated RNA Intergenic 10; GJB2, gap junction protein beta 2.