Table 2.
Summary of results of fecal calprotectin in included studies.
| Reference | FC assay | FC value (histological response /remission vs activity) | FC cut-off value (µg/g) | Intervals between FC and endoscopy | Definition | No. of patients | TP | FP | TN | FN | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Histological response | Histological remission | ||||||||||
| Cannatelli et al.23 | ELISA (Bulhmann) | 68.7 vs 810.9 (mean) | 172 | Before bowel preparation or at least 5 days after endoscopy | NI⩽1 | 76 | 27 | 13 | 35 | 1 | |
| Hart et al.22 | ELISA (Buhlmann) | 79.5 vs 148.5 (median) | 135 | 2 days | GS < 3.1 | 180 | 54 | 25 | 55 | 46 | |
| Kawashima et al.19 | Not reported | 56.2 vs 118.1 (median) | 82.7 | Within 3 days | GS < 2.0 | 74 | 29 | 12 | 22 | 11 | |
| Langhorst et al.24 | Not reported | Not reported | 50 | Within 7 days | NI ⩽ 1 | 228 | 68 | 62 | 82 | 16 | |
| Magro et al.25 | QB (Buhlmann) | 81.5 vs 231.0 (median) | 100 | Within 24 h | GS < 3.1 | 364 | 157 | 15 | 63 | 129 | |
| Magro et al.26 | QB (Buhlmann) | 73.5 vs 510.0 (median) | 237 | Within 24 h | RHI ⩽ 3a | 339 | 178 | 38 | 70 | 53 | |
| Sagami et al.21 | Colloidal gold aggregation (Alfresa) | 405 (overall median, IQR: 13 – 12517) | 100 | Within 10 days | GS ⩽ 2.0 | 39 | 9 | 4 | 21 | 5 | |
| Shi et al.20 | ELISA (Inova) | 40 (overall median, IQR: 6 – 242) | 50 | Within 3 days | NI ⩽ 1 | 139 | 64 | 11 | 40 | 24 | |
| 50 | GS < 2.0 | 139 | 60 | 15 | 48 | 16 | |||||
| Walsh et al.27 | Fcal test (Buhlmann) | 91 vs 985 (median) | 72 | Within 14 days | NI ⩽ 1 | 52 | 12 | 0 | 27 | 13 | |
ELISA, enzyme-linked immunosorbent assay; FC, fecal calprotectin; FN, false-negative; FP, false-positive; GS, Geboes score; IQR, interquartile range; NI, Nancy Index; QB, Quantum Blue; RHI, Robarts histopathology index; TN, true-negative; TP: true-positive.
a
With subscores of 0 for lamina propria neutrophils and neutrophils in the epithelium and without ulcers or erosions.