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Seasonal gene expression changes in humans. (a) Peripheral white blood cells (PBMCs, from children) and subcutaneous adipose tissue (adults). (b) A group of 68 coregulated messenger RNAs (mRNAs) with winter tropism in the human immune system, enriched for genes associated with B-lymphocyte activation (KEGG). A cosinor model was used to analyze seasonality in mRNA expression (Dopico et al., 2015). Abbreviation: PBMC = peripheral blood mononuclear cell.
