Table 3.
Univariable and Multivariable Analysis
| Univariable Analysis | Multivariable Analysis | |||||||
|---|---|---|---|---|---|---|---|---|
| P value | HR | 95% CI | P value | HR | 95% CI | |||
| LL | UL | LL | UL | |||||
| ALI | 0.031 | 0.309 | 0.107 | 0.896 | 0.009 | 0.035 | 0.003 | 0.425 |
| Gender | 0.070 | 53.193 | 0.722 | 3918.139 | 0.952 | 260,285.584 | 0 | |
| Age | 0.505 | 1.454 | 0.484 | 4.370 | ||||
| Smoking | 0.005 | 6.280 | 1.750 | 22.534 | 0.538 | 0.492 | 0.051 | 4.704 |
| PS | 0.019 | 0.276 | 0.094 | 0.809 | ||||
| CCI=0 | 0.011 | 0.137 | ||||||
| CCI=1-2 | 0.936 | 0.943 | 0.225 | 3.949 | 0.310 | 3.644 | 0.301 | 44.150 |
| CCI≥3 | 0.006 | 7.011 | 1.739 | 28.267 | 0.046 | 9.355 | 1.037 | 84.381 |
| ALB | 0.675 | 1.236 | 0.458 | 3.336 | ||||
| WBC | 0.669 | 0.806 | 0.299 | 2.170 | ||||
| RBC | 0.093 | 43.222 | 0.534 | 3495.431 | 0.955 | 292,578.176 | 0 | |
| PLT | 0.487 | 1.421 | 0.528 | 3.826 | ||||
| MONO | 0.001 | 6.590 | 2.067 | 21.015 | 0.073 | 0.225 | 0.044 | 1.151 |
| EO | 0.023 | 3.562 | 1.194 | 10.632 | 0.094 | 5.371 | 0.750 | 38.493 |
| BASO | 0.012 | 3.711 | 1.335 | 10.314 | 0.475 | 0.567 | 0.120 | 2.685 |
| NLR | 0.069 | 0.384 | 0.137 | 1.079 | 0.323 | 2.090 | 0.484 | 9.022 |
| LMR | 0.567 | 0.045 | 0 | 1813.598 | ||||
| PLR | 0.393 | 0.650 | 0.242 | 1.747 | ||||
| CEA | 0.745 | 1.184 | 0.427 | 3.289 | ||||
| LDH | 0.046 | 2.867 | 1.017 | 8.079 | 0.826 | 0.783 | 0.089 | 6.881 |
| SCC | 0.556 | 1.533 | 0.370 | 6.359 | ||||
| CYFRA21-1 | 0.127 | 2.284 | 0.790 | 6.599 | ||||
| NSE | 0.152 | 2.074 | 0.765 | 5.624 | 0.329 | 0.319 | 0.032 | 3.156 |
| BMI<18.5 | 0.243 | |||||||
| BMI[18.5,25) | 0.797 | 0.745 | 0.079 | 7.037 | ||||
| BMI≥25 | 0.114 | 2.383 | 0.812 | 6.991 | ||||
| CRP | 0.926 | 1.053 | 0.357 | 3.103 | ||||
| Pro-GRP | 0.960 | 0.946 | 0.110 | 8.136 | ||||
| Postoperative chemotherapy | 0.644 | 0.775 | 0.263 | 2.283 | ||||
Abbreviations: ALI, advanced lung cancer inflammation index; PS, performance status; CCI, Charlson comorbidity index; ALB, albumin; WBC, white blood cell; RBC, red blood cell; PLT, platelet; MONO, monocyte; EO, eosinophil; BASO, basophil; NLR, neutrophil to lymphocyte ratio; LMR, lymphocyte to monocyte ratio; PLR, platelet to lymphocyte ratio; CEA, carcinoembryonic antigen; LDH, lactate dehydrogenase; SCC, squamous cell carcinoma antigen; CYFRA 21–1, cytokeratin-19 fragment; NSE, neuron-specific enolase; BMI, body mass index; CRP, C-reactive protein; Pro-GRP, pro-gastrin releasing peptide.