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. 2020 Dec 28;7(1):17–19. doi: 10.1016/j.aace.2020.11.009

Table.

Reported Cases of SGLT2 Inhibitor Use Associated With euDKA and Low-Carbohydrate Diets in Patients With T2DM

Patient age (y) Gender Number of years patient had T2DM Number of days on a low-carbohydrate diet before developing euDKA Number of days patient took SGLT2 inhibitor before developing euDKA Plasma blood glucose (mg/dL) on admission to the hospital for euDKA HbA1C at the time of admission for euDKA Number of days patient required insulin drip Reference
32 Female 22 ∼3960 13 191 9.3% (78 mmol/mol IFCC) Unknown 17
44 Male 16 Unknown 3-4 180 9.3% (78 mmol/mol) Unknown 18
64 Female Unknown 60 365 ∼185.59 7.5% (58 mmol/mol IFCC) Unknown 19
73 Male 10 7 Unknown Unknown
Point-of-care blood glucose: 143
Unknown Unknown 20
31 Female Unknown 14 Unknown 139 Unknown Unknown 21
34a Male >5 7 ∼60 251 HbA1C 8.2% (66 mmol/mol IFCC) 3
47a Female ∼0.17 ∼60 1 187 HbA1C 13.6% (125 mmol/mol IFCC) 5

Abbreviations: euDKA = euglycemic diabetic ketoacidosis; HbA1C = hemoglobin A1C; IFCC = International Federation of Clinical Chemistry and Laboratory Medicine; SGLT2 = sodium-glucose cotransporter-2; T2DM = type 2 diabetes mellitus.

a

Patient case 1 and 2 from our report included for comparison.