Table 2.

Allelic and genotypic frequencies of polymorphisms in VEGFA, PTGS2, NOS3, TNF, and NOS2 genes in the case and control groups.

Gene	Polymorphism	Allele/Genotype	Case (n = 40)	Control (n = 48)	p-Value †
VEGFA (n, %)	rs1570360	G	70 (87%)	72 (75%)	0.054
		A	10 (13%)	24 (25%)
		GG	30 (75%)	28 (58%)	0.109
		GA	10 (25%)	16 (33%)
		AA	0	4 (9%)
	rs2010963	G	39 (49%)	47 (49%)	1.000
		C	41 (51%)	49 (51%)
		GG	11 (27%)	11 (23%)	0.821
		GC	18 (46%)	25 (52%)
		CC	11 (27%)	12 (25%)
	rs3025039	C	61 (76%)	84 (87%)	0.073
		T	19 (24%)	12 (13%)
		CC	25 (63%)	36 (75%)	0.084
		CT	11 (27%)	12 (25%)
		TT	4 (10%)	0
PTGS2 (n, %)	rs689465	T	68 (85%)	77 (80%)	0.434
		C	12 (15%)	19 (20%)
		TT	29 (73%)	30 (63%)	0.746
		TC	10 (25%)	17 (35%)
		CC	1 (2%)	1 (2%)
NOS3 (n, %)	rs2070744	T	57 (71%)	63 (66%)	0.516
		C	23 (29%)	33 (34%)
		TT	20 (50%)	21 (44%)	0.679
		TC	17 (42%)	21 (44%)
		CC	3 (8%)	6 (12%)
	rs1799983	G	65 (81%)	73 (76%)	0.464
		T	15 (19%)	23 (24%)
		GG	27 (67%)	25 (52%)	0.045 *
		TG	11 (28%)	23 (48%)
		TT	2 (5%)	0
TNF (n, %)	rs1799724	C	70 (87%)	86 (90%)	0.812
		T	10 (13%)	10 (10%)
		CC	31 (78%)	40 (83%)	0.606
		CT	8 (20%)	6 (13%)
		TT	1 (2%)	2 (4%)
	rs361525	G	76 (95%)	93 (97%)	0.703
		A	4 (5%)	3 (3%)
		GG	36 (90%)	45 (94%)	0.694
		GA	4 (10%)	3 (6%)
	rs1799964	T	63 (79%)	75 (80%)	1.000
		C	17 (21%)	19 (20%)
		TT	25 (62%)	31 (66%)	0.939
		TC	13 (33%)	13 (28%)
		CC	2 (5%)	3 (6%)
NOS2 (n, %)	rs2779249	C	28 (35%)	40 (42%)	0.437
		A	52 (65%)	56 (58%)
		CC	6 (15%)	12 (25%)	0.521
		CA	16 (40%)	16 (33%)
		AA	18 (45%)	20 (42%)
	rs2297518	G	50 (62%)	76 (79%)	0.019 *
		A	30 (38%)	20 (21%)
		GG	20 (50%)	33 (69%)	0.144
		GA	10 (25%)	10 (21%)
		AA	10 (25%)	5 (10%)

† Chi-squared test or Fisher’s exact test; * Statistically significant.