Table 3.
Frequencies of the haplotypes generated by the combination of alleles of the polymorphisms in VEGFA, NOS3, TNF, and NOS2 genes in case and control groups.
| Gene | Haplotypes † | Cases (n = 40) | Controls (n = 48) | p-Value § |
|---|---|---|---|---|
| VEGFA (n, %) | GGC | 30 (38%) | 23 (24%) | 0.002 * |
| GCC | 25 (31%) | 40 (42%) | ||
| GCT | 14 (17%) | 9 (9%) | ||
| AGC | 4 (5%) | 21 (22%) | ||
| AGT | 4 (5%) | 3 (3%) | ||
| ACC | 2 (3%) | 0 | ||
| GGT | 1 (1%) | 0 | ||
| NOS3 (n, %) | TG | 55 (69%) | 55 (57%) | 0.156 |
| CT | 14 (17%) | 15 (16%) | ||
| CG | 9 (11%) | 18 (19%) | ||
| TT | 2 (3%) | 8 (8%) | ||
| TNF (n, %) | TCG | 54 (66%) | 68 (71%) | 0.831 |
| CCG | 14 (16%) | 16 (17%) | ||
| TTG | 10 (13%) | 9 (9%) | ||
| CCA | 4 (5%) | 3 (3%) | ||
| TCG ‡ | 53 (70%) | 68 (73%) | 0.732 | |
| others ‡ | 23 (30%) | 25 (27%) | ||
| NOS2 (n, %) | GA | 37 (46%) | 51 (53%) | 0.054 |
| AA | 15 (19%) | 7 (7%) | ||
| AC | 15 (19%) | 13 (14%) | ||
| GC | 13 (16%) | 25 (26%) |
† VEGFA haplotypes: variants rs1570360, rs2010963, and rs3025039, respectively; NOS3: rs2070744 and rs1799983, respectively; TNF: rs1799964, rs1799724, and rs361525, respectively; NOS2: rs2297518, and rs2779249, respectively; ‡ Comparison of the frequencies of a haplotype containing all alleles associated with low expression of the TNF against the other haplotypes; § Chi-squared test or Fisher’s exact test; * Statistically significant.