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tPA incorporated into thrombi is protected from PAI-1 inhibition. Chandler model thrombi were formed and the levels of (A) tPA, and (B) plasminogen activator inhibitor-1(PAI-1) in serum and thrombus extracts were measured by ELISA. (C) Detection of tPA by zymography showing tPA and tPA–PAI-1 in the serum and thrombus extract after incorporation 0, 20 or 40 ng/mL tPA. Data shown are mean ± SEM (n = 4). ** p < 0.01, *** p < 0.001 vs. no tPA, a p < 0.05, c p < 0.001.
