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Fibrinolysis under high and low shear conditions. Whole blood thrombi were formed in Badimon chambers on a thrombogenic surface under low (212 s−1) and high (1690 s−1) shear rates. Fibrinolysis was measured as fluorescence release in the bathing fluid over time. Thrombi formed in the (A) absence or (B) with the incorporation of tPA at 20 or 40 ng/mL (B). D-dimer levels were measured at (C) high and (D) low shear rates. Data shown are mean ± SEM (n = 7).
